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t&experiments1.locations4.Coordinates[0]t-28.0ttasks4.stimuly0.Stimulus_descrtcrosst&experiments2.locations7.Coordinates[1]t13.0t'experiments1.locations18.Coordinates[0]t-4.0t#experiments0.locations1.Location_IDt1tsubmiter.Coder_AddresstThe University of Texas Health Science Center San Antonio Research Imaging Center, M/C 6240 7703 Floyd Curl Drive San Antonio TX, 78229-3900 texperiments3.lowLevelControlq~ttasks3.response0.Responce_typet Button Presst&experiments0.locations5.Coordinates[2]t10.0t experiments2.locations1.SPI_Unitttt$experiments0.population_groups_used0tNormals t&experiments6.locations0.Coordinates[0]t-12.0tsharing.Data_Accessionq~)ttasks4.instractions.lengtht1ttasks4.Descriptiontt$experiments1.locations15.Location_IDt15t/experiments6.contrast.experienceDependentChangeq~t#experiments5.locations0.Location_IDt0texperiments.lengtht7texperiments1.locations5.Extendq~ t&experiments2.locations7.Coordinates[0]t-26.0t%experiments1.locations13.Publ_SPI_Valt6.61t&experiments6.contrast.stimulusModalityq~texperiments3.experiment_class0q~ttasks4.stimuly.lengtht1texperiments4.lowLevelControlq~t#experiments0.locations8.Location_IDt8ttasks1.response0.descriptiontt$experiments1.locations8.Publ_SPI_Valt5.49t$experiments0.locations6.Publ_SPI_Valt7.52t#experiments0.locations2.Location_IDt2t&experiments0.locations5.Coordinates[1]t-11.0t"experiments0.contrast.stimulusRateq~t&experiments1.locations8.Coordinates[2]t39.0t&experiments0.contrast.responseModalityq~t$experiments1.locations9.Publ_SPI_Valt7.69ttasks2.stimuly0.Stimulus_typeq~t experiments1.locations6.SPI_Unittttpopulation1Mean_Aget34t$experiments1.locations16.Location_IDt16t&tasks1.instractions0.Instruction_descrt9subjects responded with a button press for the letter "X"ttasks3.response0.effecttHandt!experiments1.contrast.instructionq~t$experiments1.locations10.Location_IDt10tsubmiter.isAuthorq~t"experiments5.contrast.stimulusRateq~t&experiments0.locations3.Coordinates[2]t23.0t#experiments0.locations9.Location_IDt9tpopulation1GendertMixedt&experiments0.locations5.Coordinates[0]t-12.0t&experiments1.locations8.Coordinates[1]t-52.0texperiments0.locations18.Extendq~ t#experiments0.locations3.Location_IDt3t%experiments0.locations10.Publ_SPI_Valt7.00texperiments1.locations0.Extendt texperiments1.locations21.Extendq~ ttasks2.stimuly.lengtht1t$experiments1.locations17.Location_IDt17tpopulation1Total_Subjectst12ttasks0.Descriptiontt&experiments0.locations3.Coordinates[1]t11.0t$experiments1.locations11.Location_IDt11ttasks3.task_namet2-Back DegradedtLab0tUniversity of Municht&experiments1.locations6.Coordinates[2]t21.0texperiments1.conditions1q~t/experiments2.contrast.experienceDependentChangeq~texperiments1.conditions0tFixationt&experiments1.locations8.Coordinates[0]t38.0texperiments5.locations0.Extendq~ t"experiments3.contrast.responseRateq~t experiments1.locations0.SPI_Unitttt tasks3.External_variables.lengtht2t#experiments0.locations4.Location_IDt4t&experiments6.locations2.Coordinates[2]t45.0t&experiments0.locations9.Coordinates[2]t-16.0t'experiments0.locations11.Coordinates[2]t41.0texperiments1.Namet%2-Back Degraded vs. Fixation, Normalst&experiments4.contrast.externalVariableq~t&experiments0.locations3.Coordinates[0]t48.0t$experiments1.locations18.Location_IDt18t,experiments1.functional_modalities0.Commentstttasks1.Descriptionttexperiments1.experiment_class0q~tNoteq~)t&tasks4.instractions0.Instruction_descrtt&experiments1.locations6.Coordinates[1]t22.0t$experiments3.population_groups_used1q~0t$experiments3.population_groups_used0tSchizophrenic Patientst$experiments1.locations12.Location_IDt12tCountrytGermanytexperiments2.conditions1q~texperiments2.conditions0t2-Backtexperiments5.locations.lengtht1t!experiments4.contrast.descriptiontt&experiments1.Behavioral_domain0.effecttCognition.Memory.Workingt&experiments6.locations2.Coordinates[1]t-44.0t&experiments0.locations9.Coordinates[1]t21.0t'experiments0.locations11.Coordinates[1]t-41.0tpage_tot531t experiments0.locations5.SPI_Unitttt#experiments0.locations5.Location_IDt5t new_journalq~)ttasks4.stimuly0.Stimulus_typetFixation Pointtexperiments3.locations5.Extendq~ t$experiments2.locations3.Publ_SPI_Valt4.65t$experiments1.locations1.Publ_SPI_Valt10.45t&experiments4.locations0.Coordinates[2]t6.0t"experiments3.contrast.stimulusTypeq~t*experiments5.population_groups_used.lengtht1t&experiments1.locations6.Coordinates[0]t46.0texperiments6.locations2.Extendq~ t$experiments1.locations19.Location_IDt19t&experiments5.contrast.responseModalityq~texperiments1.locations12.Extendq~ t$experiments1.locations13.Location_IDt13ttasks1.response0.effecttHandtexperiments3.conditions1q~t&experiments0.locations7.Coordinates[2]t3.0t!tasks2.stimuly0.Stimulus_modalityq~.texperiments3.conditions0q~t&experiments6.locations2.Coordinates[0]t30.0t&experiments0.locations9.Coordinates[0]t34.0t'experiments0.locations11.Coordinates[0]t46.0texperiments2.Contexts0q~t#experiments0.locations6.Location_IDt6t&experiments4.locations0.Coordinates[1]t-7.0tProse_descriptiontMSchizophrenic patients and normal subjects underwent 2 sessions and 5 conditions. Session 1: Before Quetiapine. Session 2: After Quetiapine. Condition 1: 0-Back: subjects viewed letters on a black background and responded with a button press for the letter "X". Condition 2: 0-Back Degraded: subjects viewed letters on a blurred background and responded with a button press for the letter "X". Condition 3: 2-Back: subjects viewed letters on a black background and responded with a button press when the presented letter was the same as the one presented 2 letters back. Condition 4: 2-Back Degraded: subjects viewed letters on a blurry background and responded with a button press when the presented letter was the same as the one presented 2 letters back. Condition 5: Fixation. Experiment 1: 2-Back vs. Fixation, Normals. Experiment 2: 2-Back Degraded vs. Fixation, Normals. Experiment 3: 2-Back vs. Fixation, Normals vs. Schizophrenics, Before Treatment. Experiment 4: 2-Back Degraded vs. Fixation, Normals vs. Schizophrenics, Before Treatment. Experiment 5: 2-Back Degraded vs. Fixation, Schizophrenics vs. Normals, Before Treatment. Experiment 6: 2-Back vs. Fixation, Schizophrenics, After Treatment vs. Before Treatment. Experiment 7: 2-Back Degraded vs. Fixation, Schizophrenics, After Treatment vs. Before Treatment.t#experiments0.locations0.Location_IDt0t!experiments6.contrast.instructionq~t"experiments1.contrast.responseTypeq~t%experiments0.locations19.Publ_SPI_Valt7.89tsubmiter.Coder_Namet Sarah Thelentexperiments3.locations0.Extendq~ t keywords4t%functional magnetic resonance imagingt,experiments4.functional_modalities0.Commentstt keywords3t quetiapinet keywords2tneuroleptic treatmentt&experiments0.locations7.Coordinates[1]t-19.0t keywords1t schizophreniat$experiments1.locations14.Location_IDt14t keywords0tworking memorytexperiments3.Sessions0q~tsessions.lengtht2texperiments4.conditions1q~texperiments4.conditions0q~t experiments2.locations6.SPI_Unitttt&experiments4.locations0.Coordinates[0]t-59.0t!experiments1.locations16.SPI_Unitttt#experiments0.locations7.Location_IDt7t"experiments6.contrast.responseTypeq~t'experiments0.locations15.Coordinates[2]t15.0tsharing.Site_URLq~)ttasks0.External_descriptiontt!experiments0.locations17.SPI_Unitttts_n.Prose_descriptiontSPM 99t&experiments0.locations7.Coordinates[0]t6.0texperiments0.locations2.Extendq~ t!experiments1.locations11.SPI_Unittttauthors9tRiedel Mtauthors8t Schmitt Gtauthors7t Zetzsche Ttexperiments5.conditions1q~tauthors6tKoutsouleris Ntexperiments5.conditions0q~tauthors5tFrodl Ttauthors4t Wiesmann Mtauthors3tUfer Stauthors2tZipse Mtexperiments2.NametA2-Back vs. Fixation, Normals vs. Schizophrenics, Before Treatmenttauthors1tScheuerecker Jt!experiments0.locations12.SPI_Unittttauthors0tMeisenzahl E Mt$experiments6.population_groups_used0q~t'experiments0.locations15.Coordinates[1]t42.0tpaper_idt0texperiments3.locations.lengtht6t%experiments1.locations14.Publ_SPI_Valt6.44texperiments4.locations2.Extendq~ t&experiments6.Behavioral_domain0.effectq~'t$experiments0.locations7.Publ_SPI_Valt6.91t$experiments4.locations0.Publ_SPI_Valt6.05texperiments0.Contexts.lengtht1t$experiments4.locations1.Publ_SPI_Valt4.10t Completionq~tsubmiterq~ttasks0.response.lengtht1t'experiments0.locations13.Coordinates[2]t49.0texperiments6.conditions1q~t!experiments1.locations22.SPI_Unittttexperiments6.conditions0q~texperiments5.lowLevelControlq~t$experiments0.experiment_class.lengtht1t'experiments0.locations15.Coordinates[0]t-34.0tpopulation0Native_Langq~texperiments0.conditions1q~texperiments0.conditions0q~ttasks0.External_variables1t Response Timet#experiments2.locations0.Location_IDt0t$experiments1.locations20.Location_IDt20ttasks0.External_variables0tAccuracyt page_fromt522texperiments5.conditions.lengtht2t experiments4.locations2.SPI_Unitttt"experiments2.contrast.stimulusRateq~texperiments2.locations7.Extendq~ t%experiments0.locations11.Publ_SPI_Valt5.96t authors14t Moller H Jt authors13t Bruckmann Ht authors12tLinn Jt experiments1.locations5.SPI_Unitttt authors11t Dehning St'experiments0.locations13.Coordinates[1]t-60.0t authors10t Spellmann Itsessions0.Descriptiont8Subjects were scanned prior to receiving any medication.t%experiments0.locations12.Publ_SPI_Valt5.67t tasks1.External_variables.lengtht2t,experiments1.functional_modalities0.Modalityq~t#experiments2.locations7.Location_IDt7t&experiments4.locations2.Coordinates[2]t12.0tpopulation1Native_Langq~t#experiments2.locations1.Location_IDt1t$experiments1.locations21.Location_IDt21t'experiments0.locations19.Coordinates[2]t28.0t&experiments2.contrast.externalVariableq~t!experiments0.contrast.instructionq~ttasks0.stimuly0.Stimulus_descrt-subjects viewed letters on a black backgroundt'experiments1.locations11.Coordinates[2]t25.0texperiments1.locations17.Extendq~ texperiments0.locations17.Extendq~ t'experiments0.locations13.Coordinates[0]t32.0t"experiments0.contrast.responseRateq~tsubmiter.Coder_EmailtThelenS@uthscsa.edutexperiments1.locations20.Extendq~ tsessions1.DescriptiontBSubjects were scanned after 12 weeks of steady state treatment with quetiapine. On Day 1 of treatment they received 50 mg, on Day 2 they received 100 mg, followed by daily increases of 100 mg/day to 600 mg/day on Day 7. After Day 7 the dose of medication was adjusted according to the investigators' clinical judgement. t&experiments4.locations2.Coordinates[1]t-25.0tYeart2006texperiments2.locations2.Extendq~ t tasks4.instractions0.InstructiontFixatet%experiments5.Behavioral_domain.lengtht1t'experiments0.locations19.Coordinates[1]t32.0t#experiments2.locations2.Location_IDt2t&experiments2.locations0.Coordinates[2]t2.0t$experiments1.locations22.Location_IDt22t'experiments1.locations11.Coordinates[1]t-28.0t"experiments5.contrast.responseRateq~texperiments1.locations.lengtht23t&experiments3.contrast.responseModalityq~t tasks.lengtht5t&experiments4.locations2.Coordinates[0]t-51.0texperiments3.NametJ2-Back Degraded vs. Fixation, Normals vs. Schizophrenics, Before 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Presst!experiments5.contrast.instructionq~t&experiments2.locations4.Coordinates[2]t9.0t#experiments2.locations5.Location_IDt5t&experiments4.Behavioral_domain0.effectq~t experiments2.locations5.SPI_Unitttt'experiments1.locations15.Coordinates[1]t-13.0tCitytMunicht$experiments0.locations15.Location_IDt15t!experiments1.locations15.SPI_Unitttt&experiments3.locations1.Coordinates[1]t17.0texperiments3.Contexts0q~t%experiments1.locations15.Publ_SPI_Valt5.19t experiments2.locations0.SPI_Unitttt!experiments0.locations16.SPI_Unitttt%experiments1.locations16.Publ_SPI_Valt5.72texperiments1.conditions.lengtht2t!experiments1.locations10.SPI_Unitttt$experiments0.locations8.Publ_SPI_Valt7.74t&experiments2.locations4.Coordinates[1]t0.0t'experiments1.locations13.Coordinates[2]t28.0t'experiments1.locations15.Coordinates[0]t6.0t$experiments0.locations9.Publ_SPI_Valt7.20t$experiments4.locations2.Publ_SPI_Valt4.01t$experiments3.locations0.Publ_SPI_Valt4.78t#experiments2.locations6.Location_IDt6t!experiments0.locations11.SPI_Unittttpopulation0Genderq~ptexperiments4.Sessions0q~texperiments4.NametJ2-Back Degraded vs. Fixation, Schizophrenics vs. Normals, Before Treatmenttsubmiter.Coder_Phonet 210.567.8175texperiments5.singleSubjectq~t&experiments3.locations1.Coordinates[0]t44.0t$experiments0.locations16.Location_IDt16texperiments1.locations4.Extendq~ t$experiments0.locations10.Location_IDt10ttasks3.response0.descriptionttexperiments1.Contexts.lengtht1tpopulation0.Diagnosis_Desct11 Males, 1 Female 9 patients were drug naive and 3 had been washed out over a period of 3 days, ending 2 days before the beginning of the trial.texperiments4.locations1.Extendq~ t$experiments6.experiment_class.lengtht1t&experiments2.locations2.Coordinates[2]t-6.0ttasks1.response.lengtht1t&tasks0.instractions0.Instruction_descrt9subjects responded with a button press for the letter "X"t&experiments2.locations4.Coordinates[0]t24.0t'experiments1.locations13.Coordinates[1]t27.0texperiments6.lowLevelControlq~tpopulation1Age_Fromt22tpopulation0Total_Subjectst12t&experiments0.contrast.externalVariableq~t!experiments1.locations21.SPI_Unitttt%experiments0.locations13.Publ_SPI_Valt5.63texperiments2.Contexts.lengtht1t$experiments0.locations17.Location_IDt17t'experiments1.locations19.Coordinates[2]t44.0t$experiments0.locations11.Location_IDt11ttasks2.response.lengtht1t&experiments2.locations2.Coordinates[1]t23.0t experiments4.locations1.SPI_Unittttexperiments2.singleSubjectq~t&experiments3.locations5.Coordinates[2]t23.0t'experiments1.locations13.Coordinates[0]t8.0texperiments5.contrast.sessionq~texperiments5.contrast.groupq~t tasks2.instractions0.InstructiontRecallt&experiments0.locations0.Coordinates[2]t-9.0t experiments1.locations4.SPI_Unittttexperiments1.contrast.sessionq~texperiments2.locations6.Extendq~ 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t%experiments1.locations17.Publ_SPI_Valt5.58t"experiments5.contrast.responseTypeq~texperiments1.locations8.Extendq~ tjournalt9European Archives of Psychiatry and Clinical Neurosciencet experiments2.locations4.SPI_Unitttt&experiments0.locations2.Coordinates[2]t48.0t$experiments4.locations3.Publ_SPI_Valt3.83t$experiments3.locations1.Publ_SPI_Valt4.63ttasks3.stimuly0.Stimulus_typeq~t!experiments1.locations14.SPI_Unitttt&experiments1.locations7.Coordinates[1]t-58.0t!experiments4.contrast.instructionq~texperiments6.experiment_class0q~t!experiments0.locations15.SPI_Unitttt,experiments6.functional_modalities0.Commentstttasks2.response0.effecttHandttasks1.stimuly.lengtht1ttasks0.response0.descriptiontt&experiments0.locations2.Coordinates[1]t-44.0t&experiments1.locations5.Coordinates[2]t36.0t!experiments0.locations10.SPI_Unitttt&experiments1.locations7.Coordinates[0]t30.0t)experiments5.functional_modalities.lengtht1t tasks0.instractions0.Instructionq~ut%experiments0.locations14.Publ_SPI_Valt5.54texperiments6.NametR2-Back Degraded vs. Fixation, Schizophrenics, After Treatment vs. Before Treatmentt experiments1.locations9.SPI_Unitttttasks3.External_variables1t Response Timettasks3.External_variables0tAccuracytexperiments1.locations3.Extendq~ t&experiments6.locations1.Coordinates[2]t1.0texperiments4.Contexts0q~t,experiments0.functional_modalities0.Modalityq~texperiments4.locations0.Extendq~ t"experiments4.contrast.stimulusRateq~t&experiments0.locations2.Coordinates[0]t-42.0texperiments0.Sessions0q~t&experiments1.locations5.Coordinates[1]t10.0texperiments3.Contexts.lengtht1t!experiments1.locations20.SPI_Unitttttasks3.response.lengtht1t/experiments4.contrast.experienceDependentChangeq~t&experiments6.locations1.Coordinates[1]t-58.0texperiments5.Sessions1q~texperiments5.Sessions0q~t experiments4.locations0.SPI_Unittttexperiments0.experiment_class0q~tsharing.Sity_Nameq~)t workspaceUrlttexperiments4.Contexts.lengtht1t&experiments1.locations5.Coordinates[0]t-42.0t experiments1.locations3.SPI_Unitttttasks4.response.lengtht1texperiments2.locations5.Extendq~ tpopulation0.Diagnosist Schizophreniat&experiments0.locations6.Coordinates[2]t9.0t$experiments0.locations2.Publ_SPI_Valt5.65t&experiments6.locations1.Coordinates[0]t16.0texperiments4.experiment_class0q~t$experiments2.locations7.Publ_SPI_Valt5.86t$experiments1.locations5.Publ_SPI_Valt8.52t$experiments6.locations0.Publ_SPI_Valt5.55texperiments0.Contexts0tNormal Mappingt$experiments6.locations1.Publ_SPI_Valt5.52tsessions0.Nameq~t%experiments1.locations22.Publ_SPI_Valt4.87ttasks0.instractions.lengtht1t$experiments2.experiment_class.lengtht1t,experiments3.functional_modalities0.Modalityq~t&experiments3.contrast.externalVariableq~t tasks4.External_variables.lengtht1ttasks0.response0.effecttHandtexperiments1.locations15.Extendq~ t experiments0.locations8.SPI_Unittttexperiments0.locations15.Extendq~ t&experiments0.locations6.Coordinates[1]t2.0t&experiments0.contrast.stimulusModalityq~t&experiments1.locations9.Coordinates[2]t19.0t%experiments4.Behavioral_domain.lengtht1t)experiments4.functional_modalities.lengtht1t#experiments1.locations0.Location_IDt0t experiments6.locations1.SPI_Unittttpopulation0Age_Fromt20texperiments2.locations0.Extendq~ ttitletEffects of treatment with the atypical neuroleptic quetiapine on working memory function: A functional MRI follow-up investigationt/experiments0.contrast.experienceDependentChangeq~t experiments3.locations4.SPI_Unitttt&experiments0.locations4.Coordinates[2]t15.0t&experiments0.locations6.Coordinates[0]t-10.0t*experiments1.population_groups_used.lengtht1t&experiments1.locations9.Coordinates[1]t32.0t&experiments4.contrast.responseModalityq~texperiments2.Sessions.lengtht1t&experiments5.locations0.Coordinates[2]t2.0ttasks2.stimuly0.Stimulus_descrt-subjects viewed letters on a black backgroundt#experiments1.locations1.Location_IDt1ttasks3.External_descriptiontt%experiments1.Behavioral_domain.lengtht1texperiments0.locations10.Extendq~ texperiments1.locations10.Extendq~ t experiments0.locations2.SPI_Unitttttasks1.response0.Responce_typet Button Presst&experiments0.locations4.Coordinates[1]t22.0texperiments3.Sessions.lengtht1t&experiments1.locations9.Coordinates[0]t-6.0t#experiments6.locations0.Location_IDt0texperiments0.locations5.Extendq~ t,experiments6.functional_modalities0.Modalityq~t!experiments1.locations19.SPI_Unitttttasks4.External_variables0tNonet&experiments5.locations0.Coordinates[1]t29.0t#experiments1.locations8.Location_IDt8texperiments6.locations.lengtht3texperiments3.locations2.Extendq~ t'experiments0.locations12.Coordinates[2]t24.0t#experiments1.locations2.Location_IDt2texperiments2.locations.lengtht8texperiments4.singleSubjectq~t%experiments1.locations18.Publ_SPI_Valt5.50t&experiments0.locations4.Coordinates[0]t51.0t!experiments1.contrast.descriptiontt$experiments3.locations2.Publ_SPI_Valt4.47t$experiments2.locations0.Publ_SPI_Valt5.94t"experiments2.contrast.responseTypeq~t#experiments6.locations1.Location_IDt1t&experiments5.locations0.Coordinates[0]t-28.0texperiments0.lowLevelControlq~t'experiments0.locations12.Coordinates[1]t-40.0t experiments5.locations0.SPI_Unitttt#experiments1.locations9.Location_IDt9t)experiments3.functional_modalities.lengtht1t$experiments5.experiment_class.lengtht1t#experiments1.locations3.Location_IDt3tsessions1.Nameq~t&experiments4.locations1.Coordinates[2]t16.0ttasks1.task_namet0-Back Degradedtexperiments0.locations0.Extendq~ t experiments2.locations3.SPI_Unittttexperiments1.locations7.Extendq~ t&experiments5.contrast.stimulusModalityq~t!experiments1.locations13.SPI_Unittttexperiments1.singleSubjectq~t'experiments1.locations10.Coordinates[2]t21.0t%experiments0.locations15.Publ_SPI_Valt5.09t&experiments0.locations8.Coordinates[2]t29.0t'experiments0.locations10.Coordinates[2]t26.0t#experiments6.locations2.Location_IDt2t'experiments0.locations12.Coordinates[0]t-63.0t%experiments0.locations16.Publ_SPI_Valt4.58t!experiments0.locations14.SPI_Unitttt!experiments3.contrast.instructionq~tpopulation0Age_Tot48tMedline_numbert17151834t&experiments4.locations1.Coordinates[1]t-21.0tsubmiter.coderTypetResearch Assistantt#experiments1.locations4.Location_IDt4ttasks1.instractions.lengtht1ttasks2.response0.descriptionttpopulation0.Nameq~t abstractBodyt?RESULTS: At baseline, healthy controls revealed increased activity in the frontal lobe, especially in regions of the prefrontal cortex. Compared to HC, SZ showed hypoactivation in the right dorsolateral prefrontal cortex (DLPFC) and the ventrolateral prefrontal cortex (VLPFC) bilaterally for the 2-back condition. In the 2-back degraded condition there was a hypoactivation in both, the right DLPFC and the VLPFC. Additionally, patients showed bilaterally decreased activation in the basalganglia in the 2-back and in the right caudatus in the 2-back degraded condition compared to healthy controls. After treatment with quetiapine, patients activations patterns were increased. The pre-post comparison of the 2-back condition revealed a significant increase of activation in the left VLPFC at a significance level of 0.001 (uncorrected). The 2-back degraded condition led to a significant activation pattern in the lingual gyrus and the right precuneus. In both wm conditions, at baseline there were no differences in reaction time but only a worse performance in SZ. After treatment, behavioural measurement of responses, including reaction time and performance, showed slight improvements in SZ, although these did not reach statistical significance. CONCLUSIONS: The neuronal networks underlying working memory are clearly altered in schizophrenia. After 12 weeks of treatment with quetiapine monotherapy, patients showed significant clinical improvement and revealed increased BOLD activity in the VLPFC during a working memory task, although there was no improvement of cognitive performance.t'experiments1.locations10.Coordinates[1]t20.0t experiments1.locations8.SPI_Unitttt"experiments1.contrast.stimulusRateq~t&experiments0.locations8.Coordinates[1]t1.0t'experiments0.locations10.Coordinates[1]t23.0texperiments1.locations2.Extendq~ t&experiments4.locations1.Coordinates[0]t-61.0ttasks4.response0.Responce_typeq~t$experiments1.population_groups_used0q~0t'experiments0.locations16.Coordinates[2]t40.0t"experiments6.contrast.stimulusRateq~t#experiments1.locations5.Location_IDt5texperiments4.locations.lengtht4t&experiments3.locations2.Coordinates[2]t12.0t%experiments1.locations10.Publ_SPI_Valt4.98t'experiments1.locations10.Coordinates[0]t-4.0texperiments0.locations.lengtht20t&experiments0.locations8.Coordinates[0]t-40.0t'experiments0.locations10.Coordinates[0]t-46.0t$experiments0.locations3.Publ_SPI_Valt8.34t&experiments1.contrast.externalVariableq~t tasks2.External_variables.lengtht2texperiments5.Contexts.lengtht2tLast_edited_datet2007-02-05 18:29:28t$experiments1.locations6.Publ_SPI_Valt9.52t$experiments0.locations4.Publ_SPI_Valt4.09t&tasks2.instractions0.Instruction_descrtqsubjects responded with a button press when the presented letter was the same as the one presented 2 letters backtexperiments1.locations19.Extendq~ texperiments0.locations19.Extendq~ t$experiments6.locations2.Publ_SPI_Valt4.76t)experiments2.functional_modalities.lengtht1t'experiments0.locations16.Coordinates[1]t10.0tsharing.Per_S_SPIq~t experiments1.locations2.SPI_Unittttexperiments5.Contexts1q~texperiments5.Contexts0q~t&experiments3.locations2.Coordinates[1]t18.0t#experiments1.locations6.Location_IDt6tpopulation0handin_typetRightt!experiments6.contrast.descriptiontt"experiments4.contrast.responseRateq~texperiments1.Sessions0q~t tasks3.instractions0.Instructionq~texperiments2.locations4.Extendq~ t&experiments0.Behavioral_domain0.effectq~texperiments6.conditions.lengtht2t'experiments1.locations14.Coordinates[2]t8.0t'experiments0.locations14.Coordinates[2]t7.0texperiments0.activationsq~t'experiments0.locations16.Coordinates[0]t-42.0t&experiments3.locations0.Coordinates[2]t41.0tpubtypet(Original Research Article, Peer Reviewedt&experiments3.locations2.Coordinates[0]t51.0texperiments0.contrast.groupq~t experiments0.locations7.SPI_Unittttpopulation1handin_typeq~t#experiments1.locations7.Location_IDt7tpopulation1.Diagnosis_Desct11 Males, 1 Femaletexperiments1.locations14.Extendq~ texperiments0.locations14.Extendq~ t'experiments1.locations14.Coordinates[1]t-5.0tpopulation1.DiagnosistNormalst experiments6.locations0.SPI_Unitttt'experiments0.locations14.Coordinates[1]t47.0t*experiments0.population_groups_used.lengtht1t Other_Labq~)texperiments6.contrast.sessionq~t&experiments3.locations0.Coordinates[1]t-37.0texperiments0.locations9.Extendq~ t"experiments4.contrast.stimulusTypeq~texperiments1.activationsq~t,experiments2.functional_modalities0.Commentstt&experiments4.locations3.Coordinates[2]t4.0t experiments3.locations3.SPI_Unittttexperiments1.Contexts0q~tpopulation1.NametNormals t/experiments5.contrast.experienceDependentChangeq~t'experiments1.locations12.Coordinates[2]t-9.0tsharing.Contact_Info.lengtht0t$experiments4.population_groups_used1q~0t'experiments1.locations14.Coordinates[0]t-12.0t$experiments4.population_groups_used0q~t'experiments0.locations14.Coordinates[0]t-36.0t&experiments3.locations0.Coordinates[0]t40.0t experiments0.locations1.SPI_Unittttexperiments0.conditions.lengtht2t&experiments4.locations3.Coordinates[1]t-11.0texperiments4.Sessions.lengtht1t multisessionq~t%experiments1.locations19.Publ_SPI_Valt5.26ttasks2.External_descriptiontttasks2.instractions.lengtht1tMonthtDectexperiments2.activationsq~t)experiments1.functional_modalities.lengtht1t Lab.lengtht1t$experiments3.locations3.Publ_SPI_Valt4.07t$experiments2.locations1.Publ_SPI_Valt5.53t&experiments2.locations1.Coordinates[2]t1.0x